Update ICSR Case

curl --request PUT \
  --url https://api.example.com/api/v1/icsr/{icsr_id} \
  --header 'Content-Type: application/json' \
  --data '
{
  "estado": "<string>",
  "gravedad": "<string>",
  "ea_causalidad": "<string>",
  "ea_desenlace": "<string>",
  "qc_realizado_por": "<string>",
  "qc_fecha": "<string>",
  "lt_fecha_envio_digemid": "<string>",
  "revision_senales": "<string>",
  "comentarios_adicionales": "<string>",
  "productos": [
    {}
  ],
  "concomitantes": [
    {}
  ],
  "seguimientos": [
    {}
  ],
  "password": "<string>",
  "final": "<string>",
  "picked_id": 123
}
'

{
  "id": 123,
  "created_at": "<string>",
  "rs_catalog_map": {
    "laboratorio": "<string>",
    "rs_vencimiento": "<string>"
  },
  "paciente_iniciales": "<string>",
  "productos": [
    {}
  ],
  "concomitantes": [
    {}
  ],
  "seguimientos": [
    {}
  ],
  "eventos": [
    {}
  ]
}

PUT

api

icsr

{icsr_id}

Update ICSR Case

curl --request PUT \
  --url https://api.example.com/api/v1/icsr/{icsr_id} \
  --header 'Content-Type: application/json' \
  --data '
{
  "estado": "<string>",
  "gravedad": "<string>",
  "ea_causalidad": "<string>",
  "ea_desenlace": "<string>",
  "qc_realizado_por": "<string>",
  "qc_fecha": "<string>",
  "lt_fecha_envio_digemid": "<string>",
  "revision_senales": "<string>",
  "comentarios_adicionales": "<string>",
  "productos": [
    {}
  ],
  "concomitantes": [
    {}
  ],
  "seguimientos": [
    {}
  ],
  "password": "<string>",
  "final": "<string>",
  "picked_id": 123
}
'

{
  "id": 123,
  "created_at": "<string>",
  "rs_catalog_map": {
    "laboratorio": "<string>",
    "rs_vencimiento": "<string>"
  },
  "paciente_iniciales": "<string>",
  "productos": [
    {}
  ],
  "concomitantes": [
    {}
  ],
  "seguimientos": [
    {}
  ],
  "eventos": [
    {}
  ]
}

Endpoints

Get Case Details

GET /api/v1/icsr/{icsr_id}

Retrieves complete case details with enriched product catalog data. Authentication: Requires permission icsr:read

Update Case (Partial)

PUT /api/v1/icsr/{icsr_id}

Updates only the fields provided in the request body. Nested arrays (productos, concomitantes, seguimientos) are only replaced if explicitly included. Authentication: Requires permission icsr:update

Update Case (Full Replace)

PUT /api/v1/icsr/{icsr_id}/full

Always replaces nested arrays (productos, concomitantes, seguimientos) even if not modified. Use this for complete form submissions. Authentication: Requires permission icsr:update

Path Parameters

icsr_id

integer

required

The unique identifier of the ICSR case to update

Request Body

All fields from the Create Case endpoint are supported. Only include fields you want to update.

Common Update Scenarios

estado

string

Update case status (e.g., from “Pendiente” to “En progreso” to “Cerrado”)

gravedad

string

Update severity classification after initial assessment

ea_causalidad

string

Update causality assessment (e.g., “Posible” → “Probable” → “Definitiva”)

ea_desenlace

string

Update event outcome as case progresses

qc_realizado_por

string

Record who performed quality control review

qc_fecha

string

Record when quality control was performed

lt_fecha_envio_digemid

string

Record actual DIGEMID submission date

revision_senales

string

Add signal detection notes

comentarios_adicionales

string

Add additional case notes or comments

Updating Nested Arrays

productos

array

Replace all suspected products. Must include complete product objects with all desired fields.

concomitantes

array

Replace all concomitant medications. Must include complete objects.

seguimientos

array

Replace all followup entries. Must include complete objects.

Response (GET)

Get Case Details Response

integer

Case identifier

created_at

string

Creation timestamp

rs_catalog_map

object

Map of sanitary registration numbers to enriched product data from the catalog. Key is normalized registration number.

Show Catalog Entry Schema

laboratorio

string

Laboratory/manufacturer name from product catalog

rs_vencimiento

string

Registration expiration date from product catalog

paciente_iniciales

string

Patient initials

productos

array

Array of suspected products. Each product may include enriched laboratorio and rs_vencimiento fields from catalog if registro_sanitario matches.

concomitantes

array

Array of concomitant medications

seguimientos

array

Array of followup entries

eventos

array

Array of adverse events (see Events API)

All other fields from the create response are included.

Response (PUT)

Returns the complete updated ICSR object with the same schema as GET.

Behavior

Partial Update (PUT /icsr/)

Only updates fields that are explicitly included in the request
Omitted fields retain their current values
Nested arrays (productos, concomitantes, seguimientos) are only replaced if the array field is included in the request
If you include productos: [] (empty array), all products will be deleted

Full Update (PUT /icsr//full)

Updates all provided scalar fields
Always replaces productos, concomitantes, and seguimientos arrays, even if not modified
Recommended for frontend form submissions where the complete state is always known

Audit Trail

All updates are logged with field-level change tracking
The audit log captures:
- User who made the change
- Timestamp
- Before/after values for each changed field
- Nested array changes (additions/removals)

Auto-Processing

When a case is updated:

Missing Data Check: If required fields are now complete, no further auto-reply is sent. If new fields are missing, an auto-reply may be triggered.
Status Progression: If a followup message is sent or evaluation is created, status automatically changes from “Pendiente” to “En progreso”.
Catalog Enrichment: Product data is automatically enriched from the product catalog based on registro_sanitario matching.

Example Requests

Update Case Status Only

PUT /api/v1/icsr/1234

{
  "estado": "Cerrado",
  "comentarios_adicionales": "Caso cerrado tras evaluación completa. Causalidad confirmada como Probable."
}

Update Causality Assessment

PUT /api/v1/icsr/1234

{
  "ea_causalidad": "Probable",
  "ea_desenlace": "Recuperado",
  "qc_realizado_por": "Dr. Juan Perez",
  "qc_fecha": "2024-01-25"
}

Add Quality Control Data

PUT /api/v1/icsr/1234

{
  "qc_realizado_por": "Maria Garcia",
  "qc_fecha": "2024-01-22",
  "revision_senales": "No se identificaron señales nuevas. Evento conocido para amoxicilina.",
  "comentarios_adicionales": "Documentación completa. Listo para envío a DIGEMID."
}

Update Products Array

PUT /api/v1/icsr/1234

{
  "productos": [
    {
      "nombre_producto": "Amoxicilina",
      "ifa": "Amoxicilina trihidratada",
      "forma_farmaceutica": "Cápsula",
      "laboratorio_pais": "Laboratorio XYZ - Perú",
      "registro_sanitario": "EE-123456",
      "nro_lote": "LOT2024-002",
      "via_administracion": "Oral",
      "dosis_frecuencia": "500mg cada 8 horas",
      "fecha_inicio": "2024-01-12",
      "fecha_fin": "2024-01-16",
      "desaparecio_al_suspender": "si"
    },
    {
      "nombre_producto": "Amoxicilina + Ácido clavulánico",
      "ifa": "Amoxicilina trihidratada + Clavulanato de potasio",
      "forma_farmaceutica": "Tableta",
      "via_administracion": "Oral",
      "dosis_frecuencia": "875/125mg cada 12 horas",
      "fecha_inicio": "2024-01-16"
    }
  ]
}

Complete Form Submission (Full Update)

PUT /api/v1/icsr/1234/full

{
  "paciente_iniciales": "JD",
  "paciente_edad": 45,
  "paciente_sexo": "M",
  "paciente_peso": 72.5,
  "reportante_nombre": "Dr. Maria Garcia",
  "reportante_email": "mgarcia@hospital.com",
  "producto_sospechoso": "Amoxicilina 500mg",
  "descripcion_evento": "Paciente desarrolló rash eritematoso generalizado 3 días después de iniciar tratamiento con amoxicilina. El rash fue pruriginoso y se resolvió tras suspender el medicamento.",
  "fecha_inicio_evento": "2024-01-15",
  "fecha_fin_evento": "2024-01-18",
  "gravedad": "No grave",
  "ea_causalidad": "Probable",
  "ea_desenlace": "Recuperado",
  "estado": "Cerrado",
  "productos": [
    {
      "nombre_producto": "Amoxicilina",
      "ifa": "Amoxicilina trihidratada",
      "registro_sanitario": "EE-123456",
      "nro_lote": "LOT2024-001",
      "via_administracion": "Oral",
      "dosis_frecuencia": "500mg cada 8 horas",
      "fecha_inicio": "2024-01-12",
      "fecha_fin": "2024-01-16",
      "desaparecio_al_suspender": "si"
    }
  ],
  "concomitantes": [],
  "seguimientos": []
}

Example Response (GET)

{
  "id": 1234,
  "created_at": "2024-01-20T10:30:00Z",
  "paciente_iniciales": "JD",
  "paciente_edad": 45,
  "paciente_sexo": "M",
  "paciente_peso": 72.5,
  "reportante_nombre": "Dr. Maria Garcia",
  "reportante_email": "mgarcia@hospital.com",
  "producto_sospechoso": "Amoxicilina 500mg",
  "descripcion_evento": "Paciente desarrolló rash eritematoso generalizado...",
  "fecha_inicio_evento": "2024-01-15",
  "fecha_fin_evento": "2024-01-18",
  "gravedad": "No grave",
  "ea_causalidad": "Probable",
  "ea_desenlace": "Recuperado",
  "estado": "Cerrado",
  "qc_realizado_por": "Dr. Juan Perez",
  "qc_fecha": "2024-01-25",
  "rs_catalog_map": {
    "EE123456": {
      "laboratorio": "Laboratorio ABC S.A.",
      "rs_vencimiento": "2026-12-31"
    }
  },
  "productos": [
    {
      "id": 5678,
      "nombre_producto": "Amoxicilina",
      "ifa": "Amoxicilina trihidratada",
      "forma_farmaceutica": "Tableta",
      "laboratorio_pais": "Laboratorio ABC - Perú",
      "registro_sanitario": "EE-123456",
      "nro_lote": "LOT2024-001",
      "via_administracion": "Oral",
      "dosis_frecuencia": "500mg cada 8 horas",
      "fecha_inicio": "2024-01-12",
      "fecha_fin": "2024-01-16",
      "desaparecio_al_suspender": "si",
      "reaparecio_reexposicion": "no_aplica",
      "laboratorio": "Laboratorio ABC S.A.",
      "rs_vencimiento": "2026-12-31"
    }
  ],
  "concomitantes": [
    {
      "id": 9012,
      "nombre_producto": "Paracetamol",
      "dosis_frecuencia": "500mg PRN",
      "via_administracion": "Oral",
      "motivo_prescripcion": "Fiebre"
    }
  ],
  "seguimientos": [],
  "eventos": [
    {
      "id": 3456,
      "icsr_id": 1234,
      "texto": "Rash eritematoso generalizado",
      "tipo_notificacion": "Inicial",
      "fecha_inicio": "2024-01-15",
      "fecha_fin": "2024-01-18",
      "gravedad": "No grave",
      "causalidad": "Probable",
      "desenlace": "Recuperado",
      "meddra_pt_code": "10037844",
      "meddra_pt_term": "Rash",
      "is_from_narrative": true
    }
  ]
}

Delete Case

DELETE /api/v1/icsr/{icsr_id}
POST /api/v1/icsr/{icsr_id}:delete

Authentication: Requires permission icsr:delete and password confirmation

Request Body (Delete)

password

string

required

Current user’s password for confirmation

Delete Summary

Before deleting, check what will be removed:

GET /api/v1/icsr/{icsr_id}/delete-summary

Response:

{
  "followups": 5,
  "snapshots": 3
}

Delete Behavior

Requires password confirmation for security
Cascades to delete all related records:
- Adverse events (icsr_eventos)
- Products (icsr_productos)
- Concomitant medications (icsr_concomitantes)
- Followup tracking (icsr_seguimientos)
- Followup messages (followup_messages)
- Case snapshots (icsr_detail_snapshots)
Cannot be undone
Audit log entry is created before deletion

Example Delete Request

DELETE /api/v1/icsr/1234

{
  "password": "my_secure_password"
}

Delete Response

{
  "ok": true,
  "deleted_id": 1234
}

Error Responses

400 Bad Request

{
  "detail": [
    {
      "loc": ["body", "paciente_edad"],
      "msg": "value is not a valid integer",
      "type": "type_error.integer"
    }
  ]
}

401 Unauthorized (Delete)

{
  "detail": "Credenciales inválidas"
}

404 Not Found

{
  "detail": "ICSR no encontrado"
}

409 Conflict (Delete)

{
  "detail": "No se puede eliminar por otras restricciones. Considera soft-delete o ON DELETE CASCADE."
}

Validation

The API validates:

Case exists before updating
User has appropriate permissions
Data types match schema
Nested objects contain required fields
Date formats are valid ISO-8601
Referenced products exist in catalog (optional validation)

Best Practices

When to Use Partial Update

Updating case status or workflow fields
Adding QC review data
Updating timeline dates
Making small corrections

When to Use Full Update

Form submissions from frontend
Bulk data imports
When you always have the complete case state
Ensuring consistency across related fields

Updating Nested Arrays

Get current state: Always GET the case first to retrieve current productos/concomitantes/seguimientos
Modify locally: Make changes to the array in your application
Send complete array: Send the full modified array in the update request
Never send partial arrays: Sending [{"nombre_producto": "X"}] will delete all other products

Create Case - Create new ICSR
List Cases - Query cases
Manage Events - Update adverse events
Duplicate Detection - Check for duplicates
Followup - Communication thread

Duplicate Detection

Check Duplicates for One Case

GET /api/v1/icsr/{icsr_id}/duplicates?days_window=60

Parameters:

days_window (integer, 1-365, default 60): Time window in days to search for duplicates based on event date

Response:

{
  "status": "review",
  "label": "Revisar",
  "color": "warning",
  "score": 0.65,
  "best_id": 1200,
  "matches": [
    {
      "id": 1200,
      "score": 0.65,
      "reasons": [
        "Iniciales iguales",
        "Fecha de nacimiento igual",
        "Producto sospechoso igual",
        "Narrativa similar (35%)"
      ],
      "fecha": "2024-01-14",
      "producto": "Amoxicilina 500mg",
      "iniciales": "JD",
      "narrativa": "Paciente desarrolló rash eritematoso..."
    }
  ]
}

Score Interpretation:

>= 0.80: Likely duplicate (status: “dup”, color: “danger”)
0.45 - 0.79: Review recommended (status: “review”, color: “warning”)
< 0.45: Likely unique (status: “unique”, color: “success”)

Set Duplicate Decision

PUT /api/v1/icsr/{icsr_id}/dup

Request Body:

final

string

Manual decision: “unico” or “duplicado”. Set to null to clear override.

picked_id

integer

If final: "duplicado", the ID of the master case. Required when marking as duplicate.

Example:

{
  "final": "duplicado",
  "picked_id": 1200
}

Response:

{
  "ok": true,
  "dup_override": "duplicado",
  "dup_of_id": 1200
}

Bulk Duplicate Check

GET /api/v1/icsr/duplicates?ids=1234&ids=1235&ids=1236

GET /api/v1/icsr/duplicates?ids=1234,1235,1236

Response: Object keyed by case ID with duplicate detection results for each.

List ICSR Cases

Manage Adverse Events

​Endpoints

​Get Case Details

​Update Case (Partial)

​Update Case (Full Replace)

​Path Parameters

​Request Body

​Common Update Scenarios

​Updating Nested Arrays

​Response (GET)

​Get Case Details Response

​Response (PUT)

​Behavior

​Partial Update (PUT /icsr/)

​Full Update (PUT /icsr//full)

​Audit Trail

​Auto-Processing

​Example Requests

​Update Case Status Only

​Update Causality Assessment

​Add Quality Control Data

​Update Products Array

​Complete Form Submission (Full Update)

​Example Response (GET)

​Delete Case

​Request Body (Delete)

​Delete Summary

​Delete Behavior

​Example Delete Request

​Delete Response

​Error Responses

​400 Bad Request

​401 Unauthorized (Delete)

​404 Not Found

​409 Conflict (Delete)

​Validation

​Best Practices

​When to Use Partial Update

​When to Use Full Update

​Updating Nested Arrays

​Related Endpoints

​Duplicate Detection

​Check Duplicates for One Case

​Set Duplicate Decision

​Bulk Duplicate Check

Endpoints

Get Case Details

Update Case (Partial)

Update Case (Full Replace)

Path Parameters

Request Body

Common Update Scenarios

Updating Nested Arrays

Response (GET)

Get Case Details Response

Response (PUT)

Behavior

Partial Update (PUT /icsr/)

Full Update (PUT /icsr//full)

Audit Trail

Auto-Processing

Example Requests

Update Case Status Only

Update Causality Assessment

Add Quality Control Data

Update Products Array

Complete Form Submission (Full Update)

Example Response (GET)

Delete Case

Request Body (Delete)

Delete Summary

Delete Behavior

Example Delete Request

Delete Response

Error Responses

400 Bad Request

401 Unauthorized (Delete)

404 Not Found

409 Conflict (Delete)

Validation

Best Practices

When to Use Partial Update

When to Use Full Update

Updating Nested Arrays

Related Endpoints

Duplicate Detection

Check Duplicates for One Case

Set Duplicate Decision

Bulk Duplicate Check